Three sisters - Georgia, Eve, and Maddy - do what they do best with life, love, and lunacy on the telephone lines that bind - when their curmudgeonly father, Lou, is admitted to a Los Angeles Hospital. After years of wild living, intermittent affection, and constant phoning, he is finally threatening to die.

Meg Ryan
as Eve Mozell Marks

Diane Keaton
as Georgia Mozell

Lisa Kudrow
as Maddy Mozell

Walter Matthau
as Lou Mozell

Adam Arkin
as Joe Marks

Jesse James
as Jesse Marks

Shaun Duke
as Dr. Omar Kunundar

Ann Bortolotti
as Ogmed Kunundar

Cloris Leachman
as Pat Mozell

Maree Cheatham
as Angie