Wayne Dobie is a shy cop whose low-key demeanor has earned him the affectionate nickname "Mad Dog." After Mad Dog saves the life of Frank Milo, a crime boss and aspiring stand-up comedian, he's offered the company of an attractive young waitress named Glory for a week. At first both are uneasy about the arrangement, but they eventually fall in love. However, the situation becomes complicated when Milo demands Glory back.

Robert De Niro
as Wayne "Mad Dog" Dobie

Uma Thurman
as Glory

Bill Murray
as Frank Milo

David Caruso
as Mike

Mike Starr
as Harold

Tom Towles
as Andrew the Beater

Kathy Baker
as Lee

Derek Anunciation
as Shooter

Doug Hara
as Driver

Evan Lionel
as Dealer in Car