At the Brentwood Asylum for the mentally ill, psychiatrist partners Jane Everest and Alex MacGregor are broken up by the new superintendent, Dr. Charles Monet, who has a low regard for women physicians. Jane and Charles clash on patient treatment, and Jane learns that Charles has a sister, Claire, with a mysterious past.

Claudette Colbert
as Dr. Jane Everest

Charles Boyer
as Dr. Charles Monet

Joan Bennett
as Sally MacGregor

Helen Vinson
as Claire Monet

Joel McCrea
as Dr. Alex MacGregor

Jean Rouverol
as Carrie Flint

Esther Dale
as Matron

Guinn 'Big Boy' Williams
as Jerry Stone

Dora Clement
as Bertha Hirst

Sam Godfrey
as Tom Hirst