Rome and Juliet follows the romantic journey and soul mating of two straight women caught in a web of forbidden love. Juliet (a conservative pre-school teacher) is a bride to be who befriends and hires Rome (a liberated businesswoman) as her wedding planner. As they go through the preparations, Rome and Juliet develop a deep friendship, a soulful connection and a love that is physically consummated. But conflicts arise when Marc, the groom, who is a young politician, shockingly discovers the ongoing relationship between the two women. Angered and humiliated, Marc calls off the wedding and a huge scandal explodes, leaving Rome and Juliet in a state of emotional turmoil.

Mylene Dizon
as Rome Miranda

Andrea Del Rosario
as Juliet Flores

Rafael Rosell
as Marc

Tessie Tomas
as Charo

Glydel Mercado
as Ate Lia

Mico Palanca
as Carlo

Lui Villaruz
as Brent

Crispin Pineda
as Manding

Liza Diño-Seguerra
as Sara

Joshua Deocareza
as Vince