Patagonia narrates the journeys of two women - one looking for her past, the other for her future. The film inter-cuts between their stories, in which one of them travels south to north through the Welsh springtime and the other east to west through the Argentine autumn.

Matthew Rhys
as Mateo

Marta Lubos
as Cerys

Nahuel Pérez Biscayart
as Alejandro

Nia Roberts
as Gwen

Matthew Gravelle
as Rhys

Rhys Parry Jones
as Martin

Duffy
as Sissy

Marco Antonio Caponi
as Diego

Gabriela Ferrero
as Eleonara

Stewart Jones
as Old Mr. Roberts