It is 1967, and Larry Gopnik, a physics professor at a quiet Midwestern university, has just been informed by his wife Judith that she is leaving him. She has fallen in love with one of his more pompous acquaintances Sy Ableman.

Michael Stuhlbarg
as Larry Gopnik

Richard Kind
as Uncle Arthur

Fred Melamed
as Sy Ableman

Sari Lennick
as Judith Gopnik

Aaron Wolff
as Danny Gopnik

Jessica McManus
as Sarah Gopnik

Peter Breitmayer
as Mr. Brandt

Brent Braunschweig
as Mitch Brandt

David Kang
as Clive Park

Benjamin Portnoe
as Danny's Reefer Buddy