The first screen adaptation of Harriet Beecher Stowe's novel to star a black man in the title role.

Sam Lucas
as Uncle Tom

Irving Cummings
as George Harris

Walter Hitchcock
as George Shelby

Hattie Delaro
as Mrs. Shelby

Master Abernathy
as George Shelby Jr. as a boy

Teresa Michelena
as Eliza

Paul Scardon
as Haley

Marie Eline
as Evangeline 'Little Eva' St. Clair

Garfield Thompson
as St. Clair

Roy Applegate
as Simon Legree