In the 1930s, eccentric animal lover Trudy adopts a sickly baby gorilla named Buddy and raises him alongside chimpanzees as if they were her human children. As Buddy grows into an 800-pound adult, his immense strength and unpredictable behavior lead to trouble, culminating in a chaotic incident at an exhibition.

Rene Russo
as Trudy Lintz

Robbie Coltrane
as Bill Lintz

Alan Cumming
as Dick Croner

Irma P. Hall
as Emma

Paul Reubens
as Professor Spatz

John Aylward
as Joe Bowman

Mimi Kennedy
as Mrs. Bowman

Philip Baker Hall
as Minister

Dane Cook
as Fair Cop

Michael Reid MacKay
as Skinny Man