30 years after the events of The Brothers McMullen, romantic entanglements plague a now fiftysomething Barry McMullen and his twentysomething kids, as well as his brother Patrick and widowed sister-in-law Molly, who are also facing similar unexpected hurdles.

Connie Britton
as Molly McMullen

Edward Burns
as Barry McMullen

Halston Sage
as Patty McMullen

Michael McGlone
as Patrick McMullen

Tracee Ellis Ross
as Nina

Shari Albert
as Susan

Juliana Canfield
as Karen

Pico Alexander
as Tommy McMullen

Brian d'Arcy James
as Walter

Stephen Badalamenti
as Dr. Sal Sabatino