Colonel William Cody, alias Buffalo Bill, intends to put an end to the dishonest relations between a gang of white swindlers and the Indian, Yellow Hand. So he goes to the chief of Yellow Hand's tribe, Wise Fox, and tries to convince him to sign a peace treaty with the Federal troops. In order to avoid this, Yellow Hand abducts Wise Fox's daughter, pretending that the soldiers have done it.

Gordon Scott
as Buffalo Bill

Ingeborg Schöner
as Mary Peterson

Mario Brega
as Donaldson

Jan Hendriks
as Monroe

Catherine Ribeiro
as Rayon-de-Lune / Silver Moon Ray

Piero Lulli
as Red

Mirko Ellis
as Yellow Hand

Hans von Borsody
as Captain Hunter

Roldano Lupi
as Colonel Peterson

Andrea Scotti
as Poker player