On a flight from Los Angeles to Paris, a mad scientist on the run from the CIA is transporting a coffin containing the body of a colleague infected with a genetically modified virus. While the 747 crosses a violent thunderstorm, the instability of the aircraft allows the corpse to get out of its container.

David Chisum
as Truman

Kristen Kerr
as Megan

Richard Tyson
as Paul Judd

Kevin J. O'Connor
as Frank

Erick Avari
as Dr. Bennett

Todd Babcock
as Co-Pilot Randy

Laura Cayouette
as Dr. Kelly

Siena Goines
as Anna

Serah D'Laine
as Cara

Heidi Marnhout
as Emily