Lifelong friends and medical school graduates Mary Stevens and Don Andrews decide to set up office together. While Mary struggles to earn respect because of her gender, Don gets caught up in his ambitions for a bigger life.

Kay Francis
as Mary Stevens

Lyle Talbot
as Don A. Andrews

Glenda Farrell
as Glenda Carroll

Thelma Todd
as Lois Cavanaugh

Harold Huber
as Tony

Una O'Connor
as Mrs. Arnell Simmons

Charles C. Wilson
as Walter Rising

Hobart Cavanaugh
as Alf Simmons

George Cooper
as Pete

John Marston
as Dr. Lane Aboard SS Bellocona