Sherlock Holmes investigates a series of so-called "pajama suicides". He knows the female villain behind them is as cunning as Moriarty and as venomous as a spider. Based on "The Sign of Four" and the short stories "The Dying Detective", "The Final Problem", "The Speckled Band" and "The Adventure of the Devil's Foot".

Basil Rathbone
as Sherlock Holmes

Nigel Bruce
as Dr. John H. Watson

Gale Sondergaard
as Adrea Spedding

Dennis Hoey
as Insp. Lestrade

Vernon Downing
as Norman Locke

Alec Craig
as Radlik

Arthur Hohl
as Adam Gilflower

Mary Gordon
as Mrs. Hudson

Teddy Infuhr
as Larry (uncredited)

Donald Stuart
as Artie - Shooting Gallery Attendant (uncredited)
CinemaSerf
This time, our dynamic duo face one of their most versatile and cunning antagonists, who is cleverly behind the inexplicable “pyjama suicides”. Wealthy and seemingly upstanding members of the community are taking their own lives, usually from behind the safety of their own locked doors, by why? Well...