A farmer's herd sickens and dies, then his family and neighbors fall ill, so he bucks the state agricultural establishment as he pursues the politically-explosive investigation of how his farm, family, and friends came to be poisoned.

Ron Howard
as Ned De Vries

Art Carney
as Walter Peary

Tarah Nutter
as Kate De Vries

David Knell
as Brandon

Barry Corbin
as Dr. Agajanian

Richard Dysart
as Dr. Morton Freeman

Michael Bond
as Dr. Bill DeJong

Jim Haynie
as Doc Vandecamp

Robert Hirschfeld
as Harold

G.W. Bailey
as Jim Laszlo