A pathologist experiments with a deaf-mute woman who is unable to scream to prove that humans die of fright due to an organism he names The Tingler that lives within each person on the spinal cord and is suppressed only when people scream when scared.

Vincent Price
as Dr. Warren Chapin

Philip Coolidge
as Oliver 'Ollie' Higgins

Judith Evelyn
as Mrs. Martha Ryerson Higgins

Darryl Hickman
as David Morris

Pamela Lincoln
as Lucy Stevens

Patricia Cutts
as Isabel Stevens Chapin

William Castle
as Prologue Host (uncredited)

Bob Gunderson
as Ryerson - Screaming Convict (uncredited)

Dal McKennon
as Projectionist (uncredited)

Leon Alton
as Member of Silent Movie Audience (uncredited)
dennyjt
William Castle was a master showman and this was his grandest triumph. He loved a gimmick, in this case Percepto, a device fitted beneath theater seats to enhance the climactic scenes by giving the patrons a short, sharp shock! Vincent Price, at his most maniacally deluded, is a pathologist who says...