Frank Raymond, grandson of the original Invisible Man, uses his family's secret chemical formula to become invisible and volunteer as an Allied spy following the attack on Pearl Harbor. He infiltrates Nazi Germany to outwit Axis agents, recover a stolen spy list, and thwart a planned aerial attack on New York City.

Ilona Massey
as Maria Sorenson

Jon Hall
as Frank Raymond

Peter Lorre
as Baron Ikito

Cedric Hardwicke
as Conrad Stauffer

J. Edward Bromberg
as Karl Heiser

Albert Bassermann
as Arnold Schmidt

John Litel
as John Gardiner

Holmes Herbert
as Sir Alfred Spencer

Keye Luke
as Surgeon

Sven Hugo Borg
as German Captain (uncredited)