Paris is prey to an invisible terror against which the police can do nothing: a sinister organization that sows chaos and death. The intrepid journalist Philippe Guérande and his partner embark on a long crusade to put an end to the crimes of the Great Vampire and Irma Vep, his dangerous accomplice. (A ten episode movie serial.)

Jean Aymé
as The Great Vampire

Édouard Mathé
as Philippe Guérande

Marcel Lévesque
as Mazamette

Théodore Thalès
as Examining Magistrate Hamel

Rita Herlor
as Mrs. Margaret Simpson

Florense Simoni
as Madame Guérande

Stacia Napierkowska
as Marfa Koutiloff - The Dancer

Louis Leubas
as Father Silence / Satanas

Musidora
as Irma Vep

Fernand Herrmann
as Juan José Moréno