In 1840s London, Dr. Thomas Bolton [Boris Karloff] dares to dream the unthinkable: experimenting with anesthesia gases to make surgery pain-free. While doing so, his demonstration before a panel of his peers ends in a horrific mishap with his patient awakening under the knife; he is forced to leave his position in disgrace. To complicate matters, he becomes addicted to his own chemical experiments and gets involved with a criminal gang led by Black Ben [Francis de Wolff], and a ruthless killer Resurrection Joe [Christopher Lee]. Unfortunately, this shady partnership leads Dr. Bolton to further ruin, culminating in his unwitting participation in murder — for which he becomes the first victim of a blackmail scheme.

Boris Karloff
as Dr. Thomas Bolton

Betta St. John
as Susan

Christopher Lee
as Resurrection Joe

Finlay Currie
as Supt. Charles Matheson

Adrienne Corri
as Rachel

Francis de Wolff
as Black Ben

Francis Matthews
as Jonathan Bolton

Frank Pettingell
as Mr. Blount

Basil Dignam
as Hospital Chairman

Nigel Green
as Insp. Donovan
talisencrw
A lot of fun watching two great horror icons together like Boris Karloff and Sir Christopher Lee. I'm so glad The Criterion Collection bothered putting this foursome out in their 'Monsters and Madmen' boxed set. Such a guilty pleasure to behold, in its intriguing period-piece script of a well-meanin...
John Chard
I'm so close to surgery without pain. Dr. Thomas Bolton is one of London's top surgeons, brilliant and fast, he is however constantly troubled by the amount of pain his patients go through, for this be a time before anaesthesia. Painstakingly working on a formula to put patients to sleep during ...