The nefarious Dr. Fu Manchu searches for the keys to the tomb of Genghis Khan, in order to fulfill a prophecy that will enable him to conquer the world. His nemesi, Dr. Nayland Smith and his associates fight to keep the evil doctor from getting his hands on the keys. In 1943 the serial was edited together into a feature movie also called Drums of Fu Manchu.

Henry Brandon
as Dr. Fu Man Chu

William Royle
as Sir Dennis Nayland Smith

Robert Kellard
as Allan Parker

Luana Walters
as Mary Randolph

Olaf Hytten
as Dr. Petrie

Tom Chatterton
as Prof. Randolph

Gloria Franklin
as Fah-Lo-Suee

John Merton
as Loki

George Cleveland
as Dr. James Parker

John Dilson
as Prof. Ezra Howard