In a Spain consumed by ambition and power, the future of an empire depends of the mind state of a single woman.

Rodolfo Sancho
as Fernando II de Aragón

Irene Escolar
as Juana I de Castilla

Raúl Mérida
as Felipe I de Castilla

Eusebio Poncela
as Cardenal Cisneros

Ramón Madaula
as Gonzalo Chacón

Jordi Díaz
as Andrés de Cabrera

Fernando Guillén Cuervo
as Gutierre Gómez de Fuensalida

Úrsula Corberó
as Margarita de Austria

Silvia Alonso
as Germana de Foix

Jose Coronado
as Maximiliano I de Habsburgo