Charles Starrett is once more cast as frontier doctor Steve Monroe in Columbia's Prairie Stranger. In the company of his comic sidekick, mail-order intern Bones (Cliff Edwards), Dr. Monroe sets up his shingle in a small Nevada town. When business is slow, Monroe and Bones take jobs as ranch-hands on a cattle spread, and while thus employed try to solve a series of mysterious livestock poisonings.

Charles Starrett
as Steven Monroe

Cliff Edwards
as 'Bones' Mallory

Patti McCarty
as Sue Evans

Forbes Murray
as Jud Evans

Frank LaRue
as Jim Dawson

Archie Twitchell
as Barton

Francis Walker
as Craig

Edmund Cobb
as Dr. Westridge