The story of the late jazz musician and classical pianist Nina Simone including her rise to fame and relationship with her manager Clifton Henderson.

Zoe Saldaña
as Nina Simone

David Oyelowo
as Clifton Henderson

Ronald Guttman
as Henri Edwards

Kevin Mambo
as Gilles, Lead Guitarist

Keith David
as Clifton's Father

Ella Joyce
as Clifton's Mom

Ken Davitian
as Club Owner

Chuma Gault
as Nina's Husband

Ella A. Thomas
as Lorraine Hansberry

Mike Epps
as Richard Pryor