Felix Yzagun Manalo is a sprawling historical epic that traces the origin of Iglesia Ni Cristo (The Church of Christ) which is established in the Philippines from its humble beginnings in 1914 through the present day.

Dennis Trillo
as Felix Ysagun Manalo

Bela Padilla
as Honorata de Guzman-Manalo (the wife of Felix Manalo)

Mylene Dizon
as Bonifacia Manalo-(Ysagun) Mozo

Rey "PJ" Abellana
as Victor Danao (husband of Pilar)

Bobby Andrews
as Apolinario Ramos

Regine Angeles
as Engracia Ramos

Antonio Aquitania
as Atanacio Morte

Raymond Bagatsing
as Carling

Roxanne Barcelo
as Praxedes Ysagun

Joem Bascon
as Lucio Silvestre