Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.

Adrien Brody
as Clive

Sarah Polley
as Elsa

Delphine Chanéac
as Dren

David Hewlett
as Barlow

Abigail Chu
as Young Dren

Stephanie Baird
as Elsa / PD

Brandon McGibbon
as Gavin

Amanda Brugel
as Melinda Finch

Simona Măicănescu
as Joan Chorot
Andres Gomez
The FX is OK and the uneasiness and thrill is always there but the script is stereotypical, weak and full of holes....
John Chard
Brundledren! Splice is a tricky picture to evaluate, for its ideas are superb. One could argue that it brings a new petri dish full of meddling scientists facing the consequences of their actions, while conversely it justifiably feels like a Cronenberg knock-off. Psychological discord is in ab...
CinemaSerf
"Clive" (Adrien Brody) and "Elsa" (Sarah Polley) are a couple of genetic engineers charged by David Hewlett's "Barlow" with discovering an important gene that could lead to huge advances in medical science. Using a mix of human and animal DNA that have varying degrees of success before the evolution...