A DNA experiment on a rare breed of spider is taking place on a NASA space shuttle, when a freak meteor shower engulfs the shuttle, causing everything to go horribly wrong. One survivor is found on the ship and watched over in a secret location deep in the California desert. The problem continues, as the survivor isn't alone, as another deadly spiders climbs out of him and goes on a rampage around the ship. Curious reporter Marci Eyre must now survive, escape and warn everyone before the spider reaches outside the desert.

Lana Parrilla
as Marci Eyre

Josh Green
as John Murphy

Oliver Macready
as Slick

Simona Williams
as Loretta Martindale

Mark Phelan
as Agent Gray

Leslie Zemeckis
as Emma

Billy Maddox
as Colonel Dixon

Mark Totty
as Commander Hooper

Jonathon Breck
as Jacobs

Nick Swarts
as Jake