The baseball player goes from wayward youth to Boston Red Sox pitcher to New York Yankees home-run hero.

William Bendix
as George Herman 'Babe' Ruth

Claire Trevor
as Claire Hodgson Ruth

Charles Bickford
as Brother Matthias

Sam Levene
as Phil Conrad

William Frawley
as Jack Dunn

Gertrude Niesen
as Nightclub Singer

Fred Lightner
as Miller Huggins

Stanley Clements
as Western Union Boy

Robert Ellis
as Babe Ruth as a Boy (as Bobby Ellis)

Lloyd Gough
as Gambler Dalton