Richard and Rachel, a couple in the throes of infertility, try to maintain their marriage as they descend deeper and deeper into the insular world of assisted reproduction and domestic adoption.

Paul Giamatti
as Richard Grimes

Kathryn Hahn
as Rachel Biegler

Kayli Carter
as Sadie Barrett

Molly Shannon
as Cynthia Grimes

John Carroll Lynch
as Charlie Grimes

Desmin Borges
as Sam

Denis O'Hare
as Dr. Dordick

Siobhan Fallon Hogan
as Beth

Emily Robinson
as Charlotte Grimes

Tracee Chimo
as Caroline