Based on Anton Chekov's "The Three Sisters" about siblings living in a college town who struggle with the death of their father and try to reconcile relationships in their own lives.

Elizabeth Banks
as Nancy Pecket

Maria Bello
as Marcia Prior Glass

Erika Christensen
as Irene Prior

Steven Culp
as Dr. Harry Glass

Tony Goldwyn
as Vincent Antonelli

Mary Stuart Masterson
as Olga Prior

Eric McCormack
as Gary Sokol

Alessandro Nivola
as Andrew Prior

Chris O'Donnell
as David Turzin

Rip Torn
as Dr. Chebrin