A large spider from the jungles of South America is accidentally transported in a crate with a dead body to America where it mates with a local spider. Soon after, the residents of a small California town disappear as the result of spider bites from the deadly spider offspring. It's up to a couple of doctors with the help of an insect exterminator to annihilate these eight legged freaks.

Jeff Daniels
as Ross Jennings

Harley Jane Kozak
as Molly Jennings

John Goodman
as Delbert McClintock

Julian Sands
as Dr. James Atherton

Brian McNamara
as Chris Collins

Stuart Pankin
as Sheriff Parsons

Henry Jones
as Dr. Sam Metcalf

Peter Jason
as Henry Beechwood

Mark L. Taylor
as Jerry Manley

James Handy
as Milton Briggs
John Chard
The itsy-bitsy spider crawled up the water spout; down came the rain and washed the spider out. When a photographer is bitten and killed by a spider in the Venezuelan jungle, his body is shipped back to his home town of Canaima in California. Unfortunately something has hitched a ride in his coff...