Hank marries the divorced Joan, who's the mother of teens Sebastian and Jessica. After living with his new family for years, Hank announces that he's getting a sex change operation. The family deserts Hank, with Jessica going her own way and Sebastian staying with his mom. But Joan becomes an alcoholic, so Sebastian moves back in with Hank — now Henrietta — who turns out to be far more supportive than anyone else.

Adrian Grenier
as Sebastian Cole

Clark Gregg
as Hank / Henrietta

Aleksa Palladino
as Mary

Margaret Colin
as Joan Cole

John Shea
as Hartley Cole

Marni Lustig
as Jessica Cole

Joan Copeland
as Grandmother Cole

Tom Lacy
as Grandfather Cole

Gabriel Macht
as Troy

Herbert Russell
as Wayne