Doctors Burke and Hare leave the confines of St Swithins for the world of general practice, stopping off on the way as patients at the Foulness Anti-cold Unit. Hare then takes up a position as junior in a well-healed G.P.'s surgery while Burke continues to sow his doctorial wild oats.

Michael Craig
as Dr. Richard Hare

Virginia Maskell
as Dr. Nicola Barrington

Leslie Phillips
as Dr. Tony Burke

James Robertson Justice
as Sir Lancelot Spratt

Nicholas Phipps
as Dr. Clive Cardew

Carole Lesley
as Miss Kitten Strudwick

John Le Mesurier
as Dr. Mincing

Joan Sims
as Dawn

Reginald Beckwith
as Wildewinde

Liz Fraser
as Leonora