Set in a small Chinese village where HIV virus is spreading rapidly as a result of illicit blood trade, Mo shu wai zhuan revolves around De Yi and Qinqin are both estranged from their respective family because of their disease and unexpectedly find love with each other by their misfortunes.

Zhang Ziyi
as Shang Qinqin

Aaron Kwok
as Zhao Deyi

Jiang Wenli
as Cook

Pu Cunxin
as Qi Quan

Wang Baoqiang
as Blabber

Tao Zeru
as

Sun Haiying
as

Li Danyang
as

Cai Guoqing
as

Li Jianhua
as