The residents of a rural mining town discover that an unfortunate chemical spill has caused hundreds of little spiders to mutate overnight to the size of SUVs. It's then up to mining engineer Chris McCormack and Sheriff Sam Parker to mobilize an eclectic group of townspeople, including the Sheriff's young son, Mike, her daughter, Ashley, and paranoid radio announcer Harlan, into battle against the bloodthirsty eight-legged beasts.

David Arquette
as Chris McCormick

Kari Wührer
as Samantha Parker

Doug E. Doug
as Harlan Griffith

Scarlett Johansson
as Ashley Parker

Rick Overton
as Pete Willis

Matt Czuchry
as Bret

Riley Smith
as Randy

Leon Rippy
as Wade

Randi Klein
as Waitress #1

Terey Summers
as Waitress #2
John Chard
Arach Attack! Spiders escape from a spider farm in Prosperity, Arizona, and become giant man eating beasts on account of toxic waste carelessly dumped in a near by river. Can the odd ball inhabitants of this Arizona town escape with their lives? Or will spiders rule the earth and lay waste to man...