On the quiet campus of the remotely-located SouthWestern University, something strange is happening. All of the dogs in the area, once loyal, gentle pets, are now banding together in wild packs and hunting down their former masters. Could the strange transformation have anything to do with the secret government experiments being conducted in the school's physics laboratory? More importantly, can the dogs be stopped before it's too late?

David McCallum
as Harlan Thompson

Sandra McCabe
as Caroline Donoghue

George Wyner
as Michael Fitzgerald

Eric Server
as Jimmy Goodman

Linda Gray
as Miss Engle

Dean Santoro
as Aintry

Holly Harris
as Mrs. Koppelman

Sterling Swanson
as Dr. Martin Koppelman

Barry Greenberg
as Howard Kaplan

Michael Davis
as Nichols