The founding of the first English colony at Jamestown, Virginia, in 1612 and the many problems that confronted the struggling colonists are depicted.

Robert Gaillard
as Sir Thomas Dale

Dolores Cassinelli
as Pocahontas

Harry Kendall
as Captain George Yeardley

Paul McAllister
as Don Diego de Molina

Leslie Austin
as John Rolfe

Brian Donlevy
as Minor Role (Uncredited)

Leslie Stowe
as The Reverend Richard Buck