The boys are a dentist and his assistant traveling to the Old West to open a new practice. Once in town, they buy a business--only to wake up the next day and see that the entire population of this bustling town had left for the California gold fields early that morning! Then, they discover an evil plot to sell out these settlers to some hostile Indians, so they spring to the rescue.

Bert Wheeler
as Roy Banks

Robert Woolsey
as Dr. Philip 'Painless' Pennington

Dorothy Lee
as Mary Blake

Harry Woods
as Hank Bewley

Ethan Laidlaw
as Trigger

Chief Thunderbird
as Chief Cyclone

Delmar Watson
as Martin

Richard Alexander
as John Little

Philip Armenta
as Indian

Harry Bernard
as Prospector